Expresión de búsqueda: PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2 
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Descriptor Inglés:   Peroxisomal Multifunctional Protein-2 
Descriptor Español:   Proteína-2 Multifuncional Peroxisomal 
Descriptor Portugués:   Proteína Multifuncional do Peroxissomo-2 
Categoría:   D08.811.520.241.300.275.500
D08.811.641.812
D08.811.682.047.436.375.640
D08.811.682.047.820.150.926
Definición Inglés:   A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity. 
Nota Histórica Inglés:   2014 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número del Registro:   55288 
Identificador Único:   D064029 

Ocurrencia en la BVS:
 

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